GEMMA, which stands for Genome

The sum total of genetic material present in an organism (LINK). The project aims to analyze the DNA of the recruited children to detect new or already known genetic variations associated with the condition

, Environment, Microbiome

The complex of microorganisms (made of a vast number of different bacteria, archaea, fungi and viruses) resident in the gut whose composition is linked to health and disease Gemma aims to characterize the development of gut microbiome composition by the analysis of stool samples, to find possible pathogens triggering the condition and to design personalized therapies

and Metabolome

is the complete set of metabolites in a biological sample. Metabolites are small molecule products of metabolism (the set of life-sustaining chemical reactions in organisms) Variations of metabolome have been associated with specific conditions. GEMMA aim to analyse metaboloma of children enrlled in the project to define the condition states and its progression, monitor responses to therapy, stratify patients based on biochemical profiles, and highlight targets for drug design (LINK)

in Autism, is a multicentre European Commission Project for exploring interactions between gut microbiome, metabolome, epigenome and immune function in order to discover new biomarkers useful for early diagnosis of autism and as potential targets for preventive personalized therapies.The European Commission has selected and financed GEMMA project as part of its Horizon 2020, the biggest EU Research and Innovation programme. The grant consists of 14,2M€ in 5-years project starting January 2019.