Multi-Omics Research in Autism
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GEMMA, which stands for Genome
The sum total of genetic material present in an organism (LINK). The project aims to analyze the DNA of the recruited children to detect new or already known genetic variations associated with the condition
, Environment, Microbiome The complex of microorganisms (made of a vast number of different bacteria, archaea, fungi and viruses) resident in the gut whose composition is linked to health and disease Gemma aims to characterize the development of gut microbiome composition by the analysis of stool samples, to find possible pathogens triggering the condition and to design personalized therapies
and Metabolome is the complete set of metabolites in a biological sample. Metabolites are small molecule products of metabolism (the set of life-sustaining chemical reactions in organisms) Variations of metabolome have been associated with specific conditions. GEMMA aim to analyse metaboloma of children enrlled in the project to define the condition states and its progression, monitor responses to therapy, stratify patients based on biochemical profiles, and highlight targets for drug design (LINK)
in Autism, is a multicentre European Commission Project for exploring interactions between gut microbiome, metabolome, epigenome and immune function in order to discover new biomarkers useful for early diagnosis of autism and as potential targets for preventive personalized therapies.The European Commission has selected and financed GEMMA project as part of its Horizon 2020, the biggest EU Research and Innovation programme. The grant consists of 14,2Mโฌ in 5-years project starting January 2019.
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News And Events
GEMMA has just published its last study about plasma and fecal metabolite profiles in autism spectrum disorder (ASD)
The study analyzed metabolic imbalances, immune dysregulation, gastrointestinal dysfunction, and altered gut microbiome composition, that often affect individuals with autism, and found implication of oxidative stress and mitochondrial dysfunction, hormone level…
Inclusive app for children in the spectrum
The GEMMA Project reports “About โฆ Inclusive applications for children in the autism spectrum”, an in-depth study carried out by the CNR Educational Technologies Institute (Italy) within the Essediquadro service (https://sd2.itd.cnr.it)…
Covid19: ๐๐๐๐๐ reports #๐ฌ๐๐ฎ๐จ๐ฅ๐๐ข๐ง๐๐ฅ๐ฎ๐ฌ๐ข๐ฏ๐๐๐๐๐ฌ๐
Covid19 emergency: #inclusiveschoolathome The GEMMA project reports the “Essediquadro training” platform created by the CNR Educational Technologies Institute and which provides qualified, certified and free training (only Italian version) on “technology…
Prof. Alessio Fasano explains GEMMA project at TV Medica
The European Community (EU) funds research to find new treatments for autism.ย “This is the goal of the EU GEMMA project” says Prof. Alessio Fasano at TV Medica. Alessio Fasano is Professor…
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If you have a child with autism
If you have a child with autism
We will monitor your childโs development and will administer an autism assessment every six months.
In case you are interest in this study please send a direct email to the center closest to you. Please find information about GEMMA recruitment criteria and centres clicking "more"
- and another child 0-6 months of age
- or are pregnant or planning a baby
We will monitor your childโs development and will administer an autism assessment every six months.
- If your child develops autism, you will receive a diagnosis as early as possible, which will allow you to access early intervention.
- If your child doesnโt develop autism, you will have access to this information at the earliest possible age.
In case you are interest in this study please send a direct email to the center closest to you. Please find information about GEMMA recruitment criteria and centres clicking "more"
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