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Multi-Omics Research in Autism

GEMMA (Genome, Environment, Microbiome and Metabolome in Autism) project is a longitudinal, observational, and prospective Autism Spectrum Disorder (ASD) study that uses a unique multi-omics model to discover potential biomarkers of ASD.

eugemma

about us

The GEMMA project team consists of an EU consortium of researchers that are funded by the European Commission as part of Horizon 2020 Program. This study team aims to develop a greater understanding of autism-related symptoms and its comorbidity to gastrointestinal dysfunction. The study is currently enrolling infants that are 0-6 months of age who already have a sibling diagnosed with Autism Spectrum Disorder (ASD). This project will provide comprehensive autism assessments for these infants starting at 12 months of age up until age 3.

Published scientific articles

Here is the list of all articles published by the GEMMA team in international journals and accessible to all 

Scientific Conferences

Here is the list of abstract published by the GEMMA team in international conferences

News

Clinical trial

In perfect line with the project’s aims, 40 newborns diagnosed with autism have been included in the clinical trial. This consists of the administration of prebiotics to restore intestinal eubiosis and improve the symptoms of the autism spectrum. The clinical evaluation is ongoing.

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Preclinical studies

To demonstrate the role of gut microbiota in ASD onset, intestinal microorganisms of autistic children and neurotypical controls were transplanted in germ free mice (mice that lack intestinal microorganisms).  The behavior of mice that had received ASD microbiota exhibit decreased exploratory and social behavior accompanied with intestinal and systemic, inflammation

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